e-mail: [email protected]
Taipei City, Taiwan
六月 2021 - Present
癌症研究：不同分子量PEG修飾在奈米顆粒對anti-PEG model 的老鼠之影響
九月 2020 - 五月 2021
台北醫學大學109學年度師生聯合學術發表會（Combining Mg-Zn-Ca Bulk Metallic Glass with Nanocomposite of Mesoporous Silica for Bone Tissue Engineering）-第二名
十月 2017 - 六月 2018
利用westernblot，分析探討在human corneal epithelial
cells, human lens epithelial
cells, Fibroblast 之 不同蛋白的表現
壁報：中華民國眼科醫學會第53次 地方學術研討會 (Upregulating Bcl-xL contributed to cell growth after LED exposure in human corneal epithelial cells
七月 2013 - 十月 2017
2018 - 2020
2012 - 2016
Aims: To demonstrate the osteogenesis in bone healing through the stimulation by degradation product from Mg-Zn-Ca BMG, and OGP released from ex-MSN to attain to bone regeneration.
Results: In vitro study showed that the released metal ions from degradation of Mg-Zn-Ca BMG could promote the cell proliferation and elevate the cells’ migration ability as well as the ALP activity and mineralization. Despite the planned MSN (without OGP) showed little inhibition in cell migration and mineralization, superior results were obtained while treating cells simultaneously with the extracted-MEM and OGP-loaded ex-MSN. This result was contributed by the OGP via enhancing the focal adhesion turnover and promoting the differentiation. Hematological analysis also confirmed the biocompatibility of this BMG/nanocomposite system. In addition, in vivo micro-CT and histological observation revealed that our system could stimulate the osteogenesis and new bone formation around the implant site.
Conclusions: We have integrated Mg-based BMG materials with OGP conjugated ex-MSN to benefit the bone regeneration in both of the in vitro and vivo study. Thus, our system may have a potential to be applied on bone tissue engineering.