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Dec 11, 2010 Deșteptarea lui Ceaucescu (13 noiembrie 1965), bazat pe Ticu Dicescu (Editura. Category:1935 births Category:2016 deaths Category:People from Alexandria Category:Romanian writers Category:Romanian memoirists Category:Romanian journalists Category:Babeș-Bolyai University alumni Category:Alexandru Ioan Cuza University alumni Category:Communist University of the TolecturesAldosterone antagonist prevents cardiac hypertrophy and remodeling in a rat model of chronic volume overload. Aldosterone antagonists are currently used for the treatment of hypertensive patients, but their effects on heart structure and function are poorly understood. We studied the effect of eplerenone on cardiac remodeling in a rat model of volume overload. Rats were subjected to aortocaval fistula to induce right heart hypertrophy and ventricular remodeling. The eplerenone group received 1 mg of eplerenone per 100 g of body weight. Fourteen days later, hemodynamic, morphometric, and protein expression data were compared with those from the control group. Eplerenone treatment resulted in a significant decrease in systolic blood pressure, cardiomyocyte cross-sectional area, and right ventricular weight without modifying left ventricular mass. Eplerenone treatment significantly decreased the expression of the prohypertrophic proteins B-type natriuretic peptide and TGF-β1 in the right ventricle, whereas the anti-hypertrophic protein sarcoplasmic reticulum Ca2+-ATPase 2a increased significantly in this organ. Eplerenone treatment also increased the expression of the antihypertrophic protein caveolin-3 and the antioxidant defense protein superoxide dismutase-2 in the right ventricle. At the end of the study, eplerenone-treated rats had a lower fractional shortening and ejection fraction compared with the control group. Eplerenone prevents the remodeling of the heart induced by volume overload in rats, reducing cardiomyocyte cross-sectional area and producing changes in the expression of cardiac proteins involved in cell growth and apoptosis.Q: How to create instance method in test class from controller class? I have a controller class, say it is ClassNameController, it has two instance methods, say Get

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