洪瑋辰 Esther Hung
Machine Learning Engineer | Python Engineer | Cloud Solutions Architect for AWS
Studied Machine Learning in an AI Lab
estherhung9409@gmail.com
(+886) 937294582
Engineer (Information Technology)
International Integrated Systems, Inc.(IISI)
November 2022 ~ June 2023
Project Engineer (Information Technology)
CHUAN KAI INTERNATIONAL CO.,LTD (CKmates)
June 2021 ~ July 2022
Major histocompatibility complex (MHC) is a set of genes about acquired immune system in vertebrates. The function of MHC is mainly to help vertebrates recognize foreign molecules. There are a lot of issues about MHC in immunity and medical science, such as the susceptibility of autoimmune diseases, adverse drug reaction, and organ transplant. In order to lower the experiments cost, researchers built the prediction model for MHC binding. We built a prediction model for the binding of MHC class I proteins and peptides, named EsMHC, based on machine learning (LibSVM, Weka, and MLP) and a new method of building models: comprehensive strategy. Comprehensive strategy in EsMHC is a strategy to integrate two methods of building models (allele-specific method and pan-allele method) for balancing of strengths and weakness. Moreover, we added MHC Allele encoding developed by ourselves to feature encoding for improving prediction speed and performance. Overall, our model has great prediction performance (AUC = 0.91, ACC = 0.89, F1 = 0.91, and MCC = 0.65). The evaluation metrics of our model are almost higher than other models.
Issued by Amazon Web Services Training and Certification on July 21, 2021
Expires on October 19, 2026
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Issued by Amazon Web Services Training and Certification on October 03, 2021
Expires on October 03, 2024
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Issued by Amazon Web Services Training and Certification on November 27, 2021
Expires on November 27, 2024
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Issued by Amazon Web Services Training and Certification on October 19, 2023
Expires on October 19, 2026
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