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張詠銓
碩士論文---存活相關網路癌症資料庫(CSDN)
碩士論文---存活相關網路癌症資料庫(CSDN)
碩士論文---存活相關網路癌症資料庫(CSDN)
By
張詠銓
・
New Taipei City, Taiwan
Connect
對於生命體或細胞存活不可或缺的基因稱做必須基因。當兩種基因干擾共同發生導致細胞死亡時,這類基因之間的交互作用可以稱之為合成致命性。到目前為止探索與生存相關的交互作用只能在透過模式生物或細胞系中結合生物實驗來完成,而不能輕易的以人體進行實驗來檢測。為此,為了探討人類癌症中生存相關的基因之間的合成交互作用,可以利用生存分析方法,該分析方法可以評估癌症患者生存數據與其他變量之間的關聯,例如患者基因表現量層級。與目前僅提供患者存活和單基因之間的關聯的存活分析資料庫相比,我們的資料庫進一步提供了基因中與生存相關的交互作用,例如合成有害及保護性交互作用。 除此之外,我們的資料庫還額外提供分析癌症中合成交互作用網絡的富集分析和網絡特徵。利用交互作用的富集分析來獲得協同網路中更準確的功能參與。網絡工具還可以為研究人員提供一個平台,用以查詢已建置癌症資料中與生存相關的基因和交互作用,或者在將來上傳他們自己的基因表現量資料來執行我們網路工具上的現有的存活相關分析。我們命名這個網路資料庫為CDSN(存活相關網路癌症資料庫)。
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