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Definition of Reputation Credits
莊子璇
工作經歷
醫學實驗室 主任 (NGS平台)
送子鳥生殖中心 • 2018.06 - 至今
主責實驗室管理，包含預算規劃、人員訓練、檢驗品管和抱怨處理
主要檢驗項目: 胚胎著床前染色體套數篩檢、廣泛型遺傳疾病帶因篩檢
Honor: 使命必達獎 • 2018 企業年度團體獎項 (連續三年國際期刊發表)
醫研部學術組 領導
送子鳥生殖中心 • 2017.06 - 至今
主責臨床試驗，包含專案規劃、統計設計與分析、IRB申請與產學合作
SCI學術期刊與歐洲生殖醫學年會(ESHRE)發表、臨床資料庫管理
Honor: 精準醫學獎 • 2017 企業年度個人獎項 (資料庫自動化)
分生醫檢師
送子鳥生殖中心 • 2014.10 - 2018.06
主責NGS檢驗執行，包含結果分析、報告核發、定期確效和檢驗諮詢
Honor: 2017 歐洲生殖醫學年會口頭發表
生殖醫學諮詢師
送子鳥生殖中心 • 2013.03 - 2014.10
主責試管嬰兒療程諮詢與精液分析，包含藥物衛教、跟診、人工受孕精液處理
Honor: 創辦人獎 • 2016 企業年度團體獎項 (生殖電子衛教系統)
助理胚胎師
宏孕不孕診所 • 2012.02 - 2013.02
主責精液分析與胚胎培養，包含胚胎室建構初期鼠胚測試
資格認證
ISO 15189 醫學實驗室
全國認證基金會 (TAF)
醫學實驗室主管
內部稽核員
LDTs 實驗室
基因體遺傳學會 (TGGS)
專任技術人員
專任報告核發人員
國際醫檢師 ASCPi
美國臨床病理學會 (ASCP)
醫檢師認證
學歷
國立台灣大學醫學院 臨床醫學所
博士 • 2021 - 2024
研究主題: 胚胎粒線體分析，統計回歸模型， 機器學習
澳洲新南威爾斯大學 生醫工程所
碩士交換生 • 2010 - 2011
研究主題: 蛋白質體純化與分析
國立台灣大學醫學院 醫技所
碩士 • 2008 - 2010
研究主題: 急性白血病、紅血球增生症與染色體端粒
國立台灣大學醫學院 醫學檢驗暨生物技術學系
學士 • 2004 - 2008
醫事檢驗師訓練、高考合格
專案
檢驗計畫 (主導)
2023 ISO 醫學實驗室/LDTs 認證
2022 建構新檢驗品項: 廣泛型遺傳帶因篩檢 (服務)
2020 升級檢驗系統: 雙NGS平行測試 (臨床試驗)
2017 升級檢驗系統: NGS/微晶片平行測試 (臨床試驗)
2014 建構分生實驗室
資料庫計畫 (設計)
2023 分生監控系統: 自動化品管系統
2021 分生報告系統: 自動化報告
2020 檢驗資料庫: 自動化LIS
2019 KPI系統: 胚胎實驗室、分生實驗室
2018 臨床資料庫: 電子化
臨床療程
Using an Interpretable Machine Learning Model to Predict Corifollitropin Alfa Protocol. Fertility & Reproduction. 2023;5:50-60. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (醫療AI模型)
A Patient Friendly Corifollitropin Alfa Protocol without Routine Pituitary Suppression in Normal Responders. PLoS One. 2016;11(4):e0154123. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (李鎡堯教授優秀論文獎)
臨床胚胎學
Reduced mitochondrial DNA content correlates with poor clinical outcomes in cryotransfers with day 6 single euploid embryos. Front Endocrinol. 2023;13:1066530. Chuang TH, Chen CY, Kuan CS, Lai HH, Hsieh CL, Lee MJ, Liang YT, Chang YJ, Chen CY, Chen SU.
Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing platform. Mol Hum Reprod. 2018;24:593-601. Chuang TH, Hsieh JY, Lee MJ, Lai HH, Hsieh CL, Wang HL, Chang YJ, Chen SU.
基因檢測
High concordance in preimplantation genetic testing for aneuploidy between automatic identification via Ion S5 and manual identification via Miseq. Sci Rep. 2021b;11:18931. Chuang TH, Wu ZH, Kuan CS, Lee MJ, Hsieh CL, Wang HL, Lai HH, Chang YJ, Chen SU.
The incidence of mosaicism for individual chromosomes in human blastocysts is correlated with chromosome length. Front Genet. 2021a;11:565348. Chuang TH, Chang YP, Lee MJ, Wang HL, Lai HH, Chen SU.
Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization. Mol Cytogenet. 2017:10:14. Lai HH, Chuang TH, Wong LK, Lee MJ, Hsieh CL, Wang HL, Chen SU.
國際醫學演講
Incorporating PGT-A in the IVF Program: An IVF Center Perspective. 2022 Asia Pacific Initiative on Reproduction Masterclass
High concordance between Ion Represeq system and Veriseq system. 2021 Asia Pacific Reproductive Health Webinar
Which accumulation is better in poor ovarian responders stratified by POSEIDON, egg or blastocyst? 2020 European Society of Human Reproduction (ESHRE)– Oral (Virtual)
Per oocyte-based efficiency in cryopreserved oocyte bank: how many donated eggs are enough? 2019 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Hong Kong, China)
Elective single embryo transfer in oocyte donation IVF: strategy, outcome, and efficiency. 2018 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Taipei, Taiwan)
Mosaicism across individual chromosome in trophectoderm biopsies by next generation sequencing: changes with chromosome length. 2017 European Society of Human Reproduction (ESHRE)– Oral (Geneva, Switzerland)
莊子璇
工作經歷
醫學實驗室 主任 (NGS平台)
送子鳥生殖中心 • 2018.06 - 至今
主責實驗室管理，包含預算規劃、人員訓練、檢驗品管和抱怨處理
主要檢驗項目: 胚胎著床前染色體套數篩檢、廣泛型遺傳疾病帶因篩檢
Honor: 使命必達獎 • 2018 企業年度團體獎項 (連續三年國際期刊發表)
醫研部學術組 領導
送子鳥生殖中心 • 2017.06 - 至今
主責臨床試驗，包含專案規劃、統計設計與分析、IRB申請與產學合作
SCI學術期刊與歐洲生殖醫學年會(ESHRE)發表、臨床資料庫管理
Honor: 精準醫學獎 • 2017 企業年度個人獎項 (資料庫自動化)
分生醫檢師
送子鳥生殖中心 • 2014.10 - 2018.06
主責NGS檢驗執行，包含結果分析、報告核發、定期確效和檢驗諮詢
Honor: 2017 歐洲生殖醫學年會口頭發表
生殖醫學諮詢師
送子鳥生殖中心 • 2013.03 - 2014.10
主責試管嬰兒療程諮詢與精液分析，包含藥物衛教、跟診、人工受孕精液處理
Honor: 創辦人獎 • 2016 企業年度團體獎項 (生殖電子衛教系統)
助理胚胎師
宏孕不孕診所 • 2012.02 - 2013.02
主責精液分析與胚胎培養，包含胚胎室建構初期鼠胚測試
資格認證
ISO 15189 醫學實驗室
全國認證基金會 (TAF)
醫學實驗室主管
內部稽核員
LDTs 實驗室
基因體遺傳學會 (TGGS)
專任技術人員
專任報告核發人員
國際醫檢師 ASCPi
美國臨床病理學會 (ASCP)
醫檢師認證
學歷
國立台灣大學醫學院 臨床醫學所
博士 • 2021 - 2024
研究主題: 胚胎粒線體分析，統計回歸模型， 機器學習
澳洲新南威爾斯大學 生醫工程所
碩士交換生 • 2010 - 2011
研究主題: 蛋白質體純化與分析
國立台灣大學醫學院 醫技所
碩士 • 2008 - 2010
研究主題: 急性白血病、紅血球增生症與染色體端粒
國立台灣大學醫學院 醫學檢驗暨生物技術學系
學士 • 2004 - 2008
醫事檢驗師訓練、高考合格
專案
檢驗計畫 (主導)
2023 ISO 醫學實驗室/LDTs 認證
2022 建構新檢驗品項: 廣泛型遺傳帶因篩檢 (服務)
2020 升級檢驗系統: 雙NGS平行測試 (臨床試驗)
2017 升級檢驗系統: NGS/微晶片平行測試 (臨床試驗)
2014 建構分生實驗室
資料庫計畫 (設計)
2023 分生監控系統: 自動化品管系統
2021 分生報告系統: 自動化報告
2020 檢驗資料庫: 自動化LIS
2019 KPI系統: 胚胎實驗室、分生實驗室
2018 臨床資料庫: 電子化
臨床療程
Using an Interpretable Machine Learning Model to Predict Corifollitropin Alfa Protocol. Fertility & Reproduction. 2023;5:50-60. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (醫療AI模型)
A Patient Friendly Corifollitropin Alfa Protocol without Routine Pituitary Suppression in Normal Responders. PLoS One. 2016;11(4):e0154123. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (李鎡堯教授優秀論文獎)
臨床胚胎學
Reduced mitochondrial DNA content correlates with poor clinical outcomes in cryotransfers with day 6 single euploid embryos. Front Endocrinol. 2023;13:1066530. Chuang TH, Chen CY, Kuan CS, Lai HH, Hsieh CL, Lee MJ, Liang YT, Chang YJ, Chen CY, Chen SU.
Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing platform. Mol Hum Reprod. 2018;24:593-601. Chuang TH, Hsieh JY, Lee MJ, Lai HH, Hsieh CL, Wang HL, Chang YJ, Chen SU.
基因檢測
High concordance in preimplantation genetic testing for aneuploidy between automatic identification via Ion S5 and manual identification via Miseq. Sci Rep. 2021b;11:18931. Chuang TH, Wu ZH, Kuan CS, Lee MJ, Hsieh CL, Wang HL, Lai HH, Chang YJ, Chen SU.
The incidence of mosaicism for individual chromosomes in human blastocysts is correlated with chromosome length. Front Genet. 2021a;11:565348. Chuang TH, Chang YP, Lee MJ, Wang HL, Lai HH, Chen SU.
Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization. Mol Cytogenet. 2017:10:14. Lai HH, Chuang TH, Wong LK, Lee MJ, Hsieh CL, Wang HL, Chen SU.
國際醫學演講
Incorporating PGT-A in the IVF Program: An IVF Center Perspective. 2022 Asia Pacific Initiative on Reproduction Masterclass
High concordance between Ion Represeq system and Veriseq system. 2021 Asia Pacific Reproductive Health Webinar
Which accumulation is better in poor ovarian responders stratified by POSEIDON, egg or blastocyst? 2020 European Society of Human Reproduction (ESHRE)– Oral (Virtual)
Per oocyte-based efficiency in cryopreserved oocyte bank: how many donated eggs are enough? 2019 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Hong Kong, China)
Elective single embryo transfer in oocyte donation IVF: strategy, outcome, and efficiency. 2018 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Taipei, Taiwan)
Mosaicism across individual chromosome in trophectoderm biopsies by next generation sequencing: changes with chromosome length. 2017 European Society of Human Reproduction (ESHRE)– Oral (Geneva, Switzerland)