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Definition of Reputation Credits
Tzu-Hsuan (Andrea) Chuang
Medical Laboratory Director - management and certification
Medical Research Head - clinical Research, Statistics
ISO 15189/LDTs Accredition , SCI publication
Tel: 0919-345-595 Email: [email protected]
Work Experience
Director, Lab of next-generation sequencing
Stork Fertility Center • Jun 2018 - Present
Laboratory management: budget plan, personnel training, QC/QA, complaint handling
Major service: preimplantation genetic testing, expanded carrier screening
Honor: Mission accomplishment award (2018 Corporate Annual Group Award)
Head of Medical Research
Stork Fertility Center • Jun 2017 - Present
Clinical trials: project plan, statistical skills (STATA, SPSS), IRB approval, academic hospitals collaboration
Data warehouse: data cleaning, outcome visualization, regression models, SCI publications (~1 per year)
Honor: Precision Medicine Award (2017 Corporate Annual Individual Award)
Senior Medical Technologist of NGS Lab
Stork Fertility Center • Oct 2014 - Jun 2018
NGS execution: testing conduction, pipeline tunning, annotation, issuing reports
Consultation: reproductive genetics
Honor: Oral presentation (2017 European Society of Human Reproduction and Embryology, ESHRE)
Reproductive healthcare consultant
Stork Fertility Center • Mar 2013 - Oct 2014
Case relationship management: IVF procedures, medication education, follow-up care
Artificial reproductive technique: semen analysis and processing for insemination
Honor: Founder's Award (2016 Corporate Annual Group Award)
Assistant embryologist
Honji Fertility Center • Feb 2012 - Feb 2013
Semen analysis, human embryo culture, artificial insemination, mouse embryo model
Professional Certification
ISO 15189 Medical Lab
Taiwan Accreditation Foundation (TAF)
Lab Director, Auditor
LDTs Medical Lab
Taiwan Genomics and Genetics Society (TGGS)
Technologist, Reporting and Issuing
Int Medical Technologist
American Society for Clinical Pathology (ASCP)
Medical Technologist (ASCPi)
Education
National Taiwan University, Graduate institute of clinical medicine
Doctor of Philosophy • Feb 2021 - Mar 2024
Research Topic: Mitochondria, Regression models, Machine learning
New South Wales University (Australia), Graduate school of biomedical engineering
Master exchange • Jun 2010 - Jun 2011
Research Topic: Perlecan purification and analysis (Human colorectal cance model)
National Taiwan University, Graduate institute of Clinical Laboratory
Master of Medical technology • 2008 - 2010
Research Topic: Acute leukemia, Erythroblastosis, Telomeres
National Taiwan University, Clinical Laboratory and Medical Science
Bachelor of Medical technology • 2004 - 2008
Medical technologist training, National medical license
Project management
Medical testing
2023 ISO 15189/LDTs Accredition
2022 Service launch: Expanded carrier screening
2020 NGS upgrade: Two NGS parallel clinical trial
2017 System change: NGS vs. aCGH parallel clinical trial
2014 Molecular biology lab setup
Data warehouse
2023 LIS upgrade: Automization QC metrices of NGS
2021 Reporting system: Automization report generation
2020 LIS setup: Automization LIS
2019 KPI system: Embryo lab, molecular biology lab
2018 Clinical database: EMR establishment
Publications https://orcid.org/0000-0003-4263-9374
Clinical strategy
Using an Interpretable Machine Learning Model to Predict Corifollitropin Alfa Protocol. Fertility & Reproduction. 2023;5:50-60. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (AI healthcare model)
A Patient Friendly Corifollitropin Alfa Protocol without Routine Pituitary Suppression in Normal Responders. PLoS One. 2016;11(4):e0154123. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (Prize paper)
Clinical embryology
Reduced mitochondrial DNA content correlates with poor clinical outcomes in cryotransfers with day 6 single euploid embryos. Front Endocrinol. 2023;13:1066530. Chuang TH, Chen CY, Kuan CS, Lai HH, Hsieh CL, Lee MJ, Liang YT, Chang YJ, Chen CY, Chen SU.
Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing platform. Mol Hum Reprod. 2018;24:593-601. Chuang TH, Hsieh JY, Lee MJ, Lai HH, Hsieh CL, Wang HL, Chang YJ, Chen SU.
Reproductive genetics
High concordance in preimplantation genetic testing for aneuploidy between automatic identification via Ion S5 and manual identification via Miseq. Sci Rep. 2021b;11:18931. Chuang TH, Wu ZH, Kuan CS, Lee MJ, Hsieh CL, Wang HL, Lai HH, Chang YJ, Chen SU.
The incidence of mosaicism for individual chromosomes in human blastocysts is correlated with chromosome length. Front Genet. 2021a;11:565348. Chuang TH, Chang YP, Lee MJ, Wang HL, Lai HH, Chen SU.
Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization. Mol Cytogenet. 2017:10:14. Lai HH, Chuang TH, Wong LK, Lee MJ, Hsieh CL, Wang HL, Chen SU.
Presentation
Incorporating PGT-A in the IVF Program: An IVF Center Perspective. 2022 Asia Pacific Initiative on Reproduction Masterclass
High concordance between Ion Represeq system and Veriseq system. 2021 Asia Pacific Reproductive Health Webinar
Which accumulation is better in poor ovarian responders stratified by POSEIDON, egg or blastocyst? 2020 European Society of Human Reproduction (ESHRE)– Oral (Virtual)
Per oocyte-based efficiency in cryopreserved oocyte bank: how many donated eggs are enough? 2019 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Hong Kong, China)
Elective single embryo transfer in oocyte donation IVF: strategy, outcome, and efficiency. 2018 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Taipei, Taiwan)
Mosaicism across individual chromosome in trophectoderm biopsies by next generation sequencing: changes with chromosome length. 2017 European Society of Human Reproduction (ESHRE)– Oral (Geneva, Switzerland)
Tzu-Hsuan (Andrea) Chuang
Medical Laboratory Director - management and certification
Medical Research Head - clinical Research, Statistics
ISO 15189/LDTs Accredition , SCI publication
Tel: 0919-345-595 Email: [email protected]
Work Experience
Director, Lab of next-generation sequencing
Stork Fertility Center • Jun 2018 - Present
Laboratory management: budget plan, personnel training, QC/QA, complaint handling
Major service: preimplantation genetic testing, expanded carrier screening
Honor: Mission accomplishment award (2018 Corporate Annual Group Award)
Head of Medical Research
Stork Fertility Center • Jun 2017 - Present
Clinical trials: project plan, statistical skills (STATA, SPSS), IRB approval, academic hospitals collaboration
Data warehouse: data cleaning, outcome visualization, regression models, SCI publications (~1 per year)
Honor: Precision Medicine Award (2017 Corporate Annual Individual Award)
Senior Medical Technologist of NGS Lab
Stork Fertility Center • Oct 2014 - Jun 2018
NGS execution: testing conduction, pipeline tunning, annotation, issuing reports
Consultation: reproductive genetics
Honor: Oral presentation (2017 European Society of Human Reproduction and Embryology, ESHRE)
Reproductive healthcare consultant
Stork Fertility Center • Mar 2013 - Oct 2014
Case relationship management: IVF procedures, medication education, follow-up care
Artificial reproductive technique: semen analysis and processing for insemination
Honor: Founder's Award (2016 Corporate Annual Group Award)
Assistant embryologist
Honji Fertility Center • Feb 2012 - Feb 2013
Semen analysis, human embryo culture, artificial insemination, mouse embryo model
Professional Certification
ISO 15189 Medical Lab
Taiwan Accreditation Foundation (TAF)
Lab Director, Auditor
LDTs Medical Lab
Taiwan Genomics and Genetics Society (TGGS)
Technologist, Reporting and Issuing
Int Medical Technologist
American Society for Clinical Pathology (ASCP)
Medical Technologist (ASCPi)
Education
National Taiwan University, Graduate institute of clinical medicine
Doctor of Philosophy • Feb 2021 - Mar 2024
Research Topic: Mitochondria, Regression models, Machine learning
New South Wales University (Australia), Graduate school of biomedical engineering
Master exchange • Jun 2010 - Jun 2011
Research Topic: Perlecan purification and analysis (Human colorectal cance model)
National Taiwan University, Graduate institute of Clinical Laboratory
Master of Medical technology • 2008 - 2010
Research Topic: Acute leukemia, Erythroblastosis, Telomeres
National Taiwan University, Clinical Laboratory and Medical Science
Bachelor of Medical technology • 2004 - 2008
Medical technologist training, National medical license
Project management
Medical testing
2023 ISO 15189/LDTs Accredition
2022 Service launch: Expanded carrier screening
2020 NGS upgrade: Two NGS parallel clinical trial
2017 System change: NGS vs. aCGH parallel clinical trial
2014 Molecular biology lab setup
Data warehouse
2023 LIS upgrade: Automization QC metrices of NGS
2021 Reporting system: Automization report generation
2020 LIS setup: Automization LIS
2019 KPI system: Embryo lab, molecular biology lab
2018 Clinical database: EMR establishment
Publications https://orcid.org/0000-0003-4263-9374
Clinical strategy
Using an Interpretable Machine Learning Model to Predict Corifollitropin Alfa Protocol. Fertility & Reproduction. 2023;5:50-60. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (AI healthcare model)
A Patient Friendly Corifollitropin Alfa Protocol without Routine Pituitary Suppression in Normal Responders. PLoS One. 2016;11(4):e0154123. Lai HH, Kuo EE, Li RS, Chuang TH, Huang YC, Hsieh JY, Chang TA, Huang YL, Hsieh WT, Su YR, and Liu M. (Prize paper)
Clinical embryology
Reduced mitochondrial DNA content correlates with poor clinical outcomes in cryotransfers with day 6 single euploid embryos. Front Endocrinol. 2023;13:1066530. Chuang TH, Chen CY, Kuan CS, Lai HH, Hsieh CL, Lee MJ, Liang YT, Chang YJ, Chen CY, Chen SU.
Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing platform. Mol Hum Reprod. 2018;24:593-601. Chuang TH, Hsieh JY, Lee MJ, Lai HH, Hsieh CL, Wang HL, Chang YJ, Chen SU.
Reproductive genetics
High concordance in preimplantation genetic testing for aneuploidy between automatic identification via Ion S5 and manual identification via Miseq. Sci Rep. 2021b;11:18931. Chuang TH, Wu ZH, Kuan CS, Lee MJ, Hsieh CL, Wang HL, Lai HH, Chang YJ, Chen SU.
The incidence of mosaicism for individual chromosomes in human blastocysts is correlated with chromosome length. Front Genet. 2021a;11:565348. Chuang TH, Chang YP, Lee MJ, Wang HL, Lai HH, Chen SU.
Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization. Mol Cytogenet. 2017:10:14. Lai HH, Chuang TH, Wong LK, Lee MJ, Hsieh CL, Wang HL, Chen SU.
Presentation
Incorporating PGT-A in the IVF Program: An IVF Center Perspective. 2022 Asia Pacific Initiative on Reproduction Masterclass
High concordance between Ion Represeq system and Veriseq system. 2021 Asia Pacific Reproductive Health Webinar
Which accumulation is better in poor ovarian responders stratified by POSEIDON, egg or blastocyst? 2020 European Society of Human Reproduction (ESHRE)– Oral (Virtual)
Per oocyte-based efficiency in cryopreserved oocyte bank: how many donated eggs are enough? 2019 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Hong Kong, China)
Elective single embryo transfer in oocyte donation IVF: strategy, outcome, and efficiency. 2018 Asia Pacific Initiative on Reproduction Congress (ASPIRE) – Oral (Taipei, Taiwan)
Mosaicism across individual chromosome in trophectoderm biopsies by next generation sequencing: changes with chromosome length. 2017 European Society of Human Reproduction (ESHRE)– Oral (Geneva, Switzerland)