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Definition of Reputation Credits
Lê Thị Hồng Hạnh
Taiwan
0937049452
[email protected]
https://www.linkedin.com/in/le-hanh-7b4182154/
I have extensive experience in metabolomics analysis, exosome purification, and drug delivery. My current research focuses on building a procedure from A to Z to analyze the metabolic changes in patients undergo 1st and 2nd stages of NAFLD, to find new biomarkers for diagnosis and prognosis purposes. My previous research was on setting up a platform for the purification of stem cell exosomes and exploring the ability of exosomes in terms of their drug delivery potential.
I am open to new fields of research with an open mind, hard work, and a good attitude toward the given tasks, with resilience and not-giving-up strength, I believe I can get the work done.
Work Experience
Graduate Research Assistant • Institute of Biological Chemistry, Academia Sinica, Taiwan
April 2021 - Present | Taipei, Taiwan
Project title: "Extensive lipidomic profiling study for new biomarkers identification in non-alcoholic fatty liver disease"
Exploration and metabolomics analysis procedure set up to gain insights into the differences between the first two-stage of non-alcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL - stage 1), and non-alcoholic steatohepatitis (NASH), with the final goal being to find potential new biomarkers for better diagnosis and prognosis of the disease. By using LC-MS analysis to examine different compartments within patients (including portal vein blood, liver, and peripheral blood), I can depict a potential group of biomarkers (sphingolipids).
Additionally, a pipeline was established for metabolomic profiling applied to different projects, including exploring the lipid changes in H.Pylori under treatment conditions and cancer pathological comparison.
My future goal is to combine metabolomics with other omics analyses to understand how NAFLD develops and the stages for a better diagnosis and treatment.
Education
National Yang-Ming University
Biopharmaceutical Sciences • 2019 - 2021
Grade: 4.1/4.3
A two-year project with the title " Establishment of a scalable and reproducible isolation process to purify mesenchymal stem cell-derived exosomes"
To explore the potential of exosomes as the nanomedicine to deliver drugs, mesenchymal stem cells were chosen as the materials, aiming at establishing a large-scale production platform and investigating the ability to pack different drugs into their exosomes. The result demonstrated a successful tangential flow filtration (TFF) platform for exosome isolation with consistency and a large-scale approach with a high recovery rate, low protein contamination, and content preservation (cytokines, miRNA). Moreover, it was used to test the drug carriers, of which the potential drug-encapsulated exosomes had better efficacy in disease treatment.
This finding expanded the idea of nature-bearing nanoparticles with a better safety profile than synthetic nanoparticles to deliver drugs to patients.
University of Science and Technology of Hanoi
Pharmacological, Medical, and Agronomical Biotechnology • 2015 - 2018
4.5 months project with the title " Synthesis of antibiotic agents with new scaffold"
The study targeted Loxapine structure (an antibiotic) by modifying its structure using a one-step reaction to suppress Salmonella Typhimurium (a Gram-negative bacteria) to avoid antibiotic resistance. By using chemistry synthesis to alter the amino group of Loxapine, a list of derivatives was built, and then further tested its inhibitory effects against the growth of Salmonella, compared with the original Loxapine structure. The hit derivatives showed their potential in lowering the IC50 of the drug, making the bacteria vulnerable to the treatment, but causing no harm to the cell.
Skills
- Metabolomics analysis (MS-Dial, Metaboanalyst, Cytoscapes, etc.)
- LC-MS/MS (Orbitrap)
- Exosome isolation and purification (Tangential Flow Filtration, Ultrafiltration)
- Cell culture
- qPCR
- Western Blotting
- Drug delivery (Bulk electroporation)
- Nanoparticle tracking analysis
- ELISA
- Statistical analysis
- R
- Microsoft office
Languages
- Vietnamese — Native or Bilingual
- English — Fluent
Lê Thị Hồng Hạnh
Taiwan
0937049452
[email protected]
https://www.linkedin.com/in/le-hanh-7b4182154/
I have extensive experience in metabolomics analysis, exosome purification, and drug delivery. My current research focuses on building a procedure from A to Z to analyze the metabolic changes in patients undergo 1st and 2nd stages of NAFLD, to find new biomarkers for diagnosis and prognosis purposes. My previous research was on setting up a platform for the purification of stem cell exosomes and exploring the ability of exosomes in terms of their drug delivery potential.
I am open to new fields of research with an open mind, hard work, and a good attitude toward the given tasks, with resilience and not-giving-up strength, I believe I can get the work done.
Work Experience
Graduate Research Assistant • Institute of Biological Chemistry, Academia Sinica, Taiwan
April 2021 - Present | Taipei, Taiwan
Project title: "Extensive lipidomic profiling study for new biomarkers identification in non-alcoholic fatty liver disease"
Exploration and metabolomics analysis procedure set up to gain insights into the differences between the first two-stage of non-alcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL - stage 1), and non-alcoholic steatohepatitis (NASH), with the final goal being to find potential new biomarkers for better diagnosis and prognosis of the disease. By using LC-MS analysis to examine different compartments within patients (including portal vein blood, liver, and peripheral blood), I can depict a potential group of biomarkers (sphingolipids).
Additionally, a pipeline was established for metabolomic profiling applied to different projects, including exploring the lipid changes in H.Pylori under treatment conditions and cancer pathological comparison.
My future goal is to combine metabolomics with other omics analyses to understand how NAFLD develops and the stages for a better diagnosis and treatment.
Education
National Yang-Ming University
Biopharmaceutical Sciences • 2019 - 2021
Grade: 4.1/4.3
A two-year project with the title " Establishment of a scalable and reproducible isolation process to purify mesenchymal stem cell-derived exosomes"
To explore the potential of exosomes as the nanomedicine to deliver drugs, mesenchymal stem cells were chosen as the materials, aiming at establishing a large-scale production platform and investigating the ability to pack different drugs into their exosomes. The result demonstrated a successful tangential flow filtration (TFF) platform for exosome isolation with consistency and a large-scale approach with a high recovery rate, low protein contamination, and content preservation (cytokines, miRNA). Moreover, it was used to test the drug carriers, of which the potential drug-encapsulated exosomes had better efficacy in disease treatment.
This finding expanded the idea of nature-bearing nanoparticles with a better safety profile than synthetic nanoparticles to deliver drugs to patients.
University of Science and Technology of Hanoi
Pharmacological, Medical, and Agronomical Biotechnology • 2015 - 2018
4.5 months project with the title " Synthesis of antibiotic agents with new scaffold"
The study targeted Loxapine structure (an antibiotic) by modifying its structure using a one-step reaction to suppress Salmonella Typhimurium (a Gram-negative bacteria) to avoid antibiotic resistance. By using chemistry synthesis to alter the amino group of Loxapine, a list of derivatives was built, and then further tested its inhibitory effects against the growth of Salmonella, compared with the original Loxapine structure. The hit derivatives showed their potential in lowering the IC50 of the drug, making the bacteria vulnerable to the treatment, but causing no harm to the cell.
Skills
- Metabolomics analysis (MS-Dial, Metaboanalyst, Cytoscapes, etc.)
- LC-MS/MS (Orbitrap)
- Exosome isolation and purification (Tangential Flow Filtration, Ultrafiltration)
- Cell culture
- qPCR
- Western Blotting
- Drug delivery (Bulk electroporation)
- Nanoparticle tracking analysis
- ELISA
- Statistical analysis
- R
- Microsoft office
Languages
- Vietnamese — Native or Bilingual
- English — Fluent